Gut

Gut microbiome in IBD: past, present and the future

IBD has become a global disease in the 21st century that shifts through four epidemiological stages. Alterations in the gut ...
Gut

Engineered virus-hunter vaccine overcomes HBV immune tolerance

Background Globally, an estimated 296 million individuals live with chronic hepatitis B virus (HBV) infection, carrying ...
gut.bmj

Spatial single-cell omics in liver studies: cautions on metanarrative pitfalls

We read with great interest the review by Suo et al published in Gut recently, ‘Spatial single-cell omics: new insights into liver diseases’.1 This very well-written and comprehensive review ...
gut.bmj

A practical guide to assess the Nancy histological index for UC

4 Inserm U954, University of Lorraine, Vandoeuvre-lès-Nancy, France Correspondence to Professor Laurent Peyrin-Biroulet, Department of Gastroenterology, Inserm U954, Université de Lorraine, Allée du ...
gut.bmj

A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis

Background Autoimmune hepatitis (AIH) is characterised by death of hepatocytes and chronic inflammation. Patients with deleterious variants in A20 are identified with AIH presentations and immune ...
gut.bmj

Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study

Background In the hepatitis B e antigen positive (HBeAg+) chronic infection disease phase, approved treatments have limited effects on hepatitis B surface antigen (HBsAg) and HBeAg. Objective The ...
gut.bmj

Guidelines on the management of common bile duct stones (CBDS)

The last 30 years have seen major developments in the management of gallstone-related disease, which in the United States alone costs over 6 billion dollars per annum to treat. Endoscopic retrograde ...
gut.bmj

An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

Background and aims Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder that may be triggered by enteric pathogens and has also been linked to alterations in the microbiota ...
gut.bmj

Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn’s disease: results from two large prospective cohort studies

Objective To examine the relationship between Mediterranean diet and risk of later-onset Crohn’s disease (CD) or ulcerative colitis (UC). Design We conducted a prospective cohort study of 83 147 ...
gut.bmj

Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

3 Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, Linköping, Sweden 4 Department of Clinical and Experimental Medicine, Division of Inflammation ...
gut.bmj

Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease

Professor J P Galmiche, Centre de Recherche en Nutrition Humaine, CRI INSERM 95-08, CHU, Hôtel Dieu, Place A Ricordeau, 44035 Nantes cedex 01, France. Email:galmiche{at}easynet.fr BACKGROUND/AIM ...
gut.bmj

Guidelines for the management of inflammatory bowel disease in adults

7 Department of Paediatrics, St George's Hospital, London, UK 8 Department of Gastroenterology, St. Mary's Hospital, London, UK 9 Department Gastroenterology, University Hospital of North Tees, UK The ...