Cellular aging is thought to be controlled, in part, by the chromosomes’ telomeres – end caps that protect our DNA. But the relationship may be much more complex than scientists thought, as new ...

Researchers have found a way to trap telomerase, the enzyme cancer cells rely on for endless division, in a stalled and ...

In humans, telomeres are nucleoprotein complexes made up of tandem 5′TTAGGG3′ DNA repeats and associated proteins located at the ends of all 46 chromosomes. Telomere (TTAGGG)n tract loss beyond a ...

Research published in Science Signaling identifies new ways that telomeres regulate the aggressiveness and survival of tumors, making them potentially vulnerable therapeutic targets for killing cancer ...

Telomers represent the region that constitutes the end of chromosomes and is protected by telomere-binding proteins. These proteins protect telomeres from being recognized as DNA double-strand breaks.

Oncotarget published "Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells" which reported that this assay is based on the use of two isogenic HT1080 ...

A new study led by researchers at the University of Pittsburgh (Pitt) and UPMC Hillman Cancer Center has shown that an enzyme called PARP1 is involved in the repair of telomeres, the lengths of DNA ...

Alternative lengthening of telomeres cells, or ALT cells, have long presented a challenge for researchers and oncologists alike. Unlike other cancer cells, which use the enzyme telomerase to lengthen ...