The novel Cleavage High-throughput Assay (CHiTA) developed at Penn State provides a scarless method to characterize thousands of diverse small self-cleaving RNA enzymes, called twister ribozymes, in a ...
SANTA CRUZ, CA — Researchers at the University of California, Santa Cruz, have determined the three-dimensional structure of an RNA enzyme, or “ribozyme,” that carries out a fundamental reaction ...
Important progress for RNA research: A team has discovered a new ribozyme that can label RNA molecules in living cells. RNA molecules are real all-rounders. They transfer the genetic information from ...
Atomic-resolution structure of a ribozyme yields insights into RNA catalysis and the origins of life
Santa Cruz, CA — Which came first, nucleic acids or proteins? This question is molecular biology’s version of the “chicken-or-the-egg” riddle. Genes made of nucleic acids (DNA or RNA) contain the ...
image: RNA world vs. modern world. Present-day organisms follow the central dogma: DNA (or RNA) encode genetic information, whereas cellular functions are carried out by proteins. In an RNA world, RNA ...
Small ribozymes such as Oryza sativa twister spontaneously cleave their own RNA when the ribozyme folds into its active conformation. The coupling between twister folding and self-cleavage has been ...
The GlmS enzyme, which is involved in GlcN6P synthesis, is translated from mRNA containing a ribozyme sequence. GlcN6P activates the ribozyme cleaving the mRNA sequence and turning enzyme production ...
The "RNA world" hypothesis proposes that the earliest life on Earth may have been based on RNA - a single-stranded molecule similar in many ways to DNA - like some modern viruses. This is because, ...
Adeno-associated virus (AAV) gene therapy holds considerable promise for treating diseases caused by genetic defects or deficiencies, but the packaging capacity of AAV vectors limits the potential ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results
Feedback