Purpose: Single genetic variants in multifactorial disorders typically have small effects, so major increases in disease risk are expected only from the simultaneous exposure to multiple risk ...

F ST is a property of the distribution of allele frequencies among populations. It reflects the joint effects of drift, migration, mutation and selection on the distribution of genetic variation among ...

The Hardy-Weinberg equilibrium principle describes the unchanging frequency of alleles and genotypes in a stable, idealized population. In this population we assume there is random mating and sexual ...

Two lines of evidence are presented to demonstrate that allelic frequency distributions are insufficient to characterize the genetic behavior of a population subject to selection. First, two methods ...

The THSD7A gene has recently been described as a "obesity gene". The product of this gene significantly modulates angiogenesis, a process linked to adipogenesis, growth of adipose tissue and the ...