Nature

Model-based meta-analysis of HbA1c reduction across SGLT2 inhibitors using dose adjusted by urinary glucose excretion

This study was aimed to evaluate whether the dose–response relationship of the sodium glucose co-transporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus (T2DM)—canagliflozin, ...
Nature

Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock

The synchronization of the circadian clock is important for many organisms to adapt to environmental changes 1,2,3. The phase response curve (PRC) summarizes the response of the circadian clock to ...
The Scientist

Challenging Dose-Response Dogma

Stylized curves that illustrate the linear, threshold, and hormetic dose-response models for carcinogens. The central pillar upon which toxicological assessments are built is the dose-response ...
BMJ

Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose–response meta-analysis of large prospective studies

Objective To estimate the dose–response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population. Design Systematic ...
BMJ

Optimal dose and type of physical activity to improve functional capacity and minimise adverse events in acutely hospitalised older adults: a systematic review with dose ...

Objective To identify the optimal dose and type of physical activity to improve functional capacity and reduce adverse events in acutely hospitalised older adults. Design Systematic review and ...
insider.si.edu

Dose-response modelling for the discolouration of iron gall ink on paper

Fearn, Tom, Strlic, Matija, and Liu, Yun. 2021. "Dose-response modelling for the discolouration of iron gall ink on paper." from Transcending Boundaries: Integrated Approaches to Conservation. ICOM-CC ...