γ-Secretase is an aspartyl intramembrane protease that cleaves the amyloid precursor protein (APP) involved in Alzheimer’s disease pathology and other transmembrane proteins. Substrate-bound ...

Amide bonds are ubiquitous in pharmaceuticals, agrochemicals and biomolecules, and their formation underpins the synthesis of peptides, proteins and small-molecule therapeutics. Traditional chemical ...

Engineered enzymes are poised to have transformative impacts across applications in energy, materials, biotechnology, and medicine. Recently, machine learning has emerged as a useful tool for enzyme ...